New diagnostic and therapeutic tools
against multidrug resistant tumours

Synthesis and nanodelivery strategies for new therapeutic tools against MDR tumours

The main objective of WG2 is to identify, via design and synthesis, new bio-active compounds that target multidrug resistance (MDR) tumours and to formulate them using nanocarriers in order to improve their solubilisation, delivery, selectivity and anticancer action using passive or active targeting, via the optimisation of pharmacokinetic properties. The identification of new substances (novel anticancer agents, natural compounds…) as modulators of MDR in tumour cells and the realisation of new pharmacological tools (nanoparticles, liposomes, self-assemblies prodrugs…) will proceed via a study of structure-activity and structure-property relationships and the clarification of MDR mechanisms. Tools and expertise will include the use of contemporary methods of synthesis and the interpretation of biological data (computational chemistry, QSAR, molecular modelling, molecular dynamics…) in order to optimise existing leads and select validated, promising and innovative pharmacological targets.

WG2 Members

Total 74 participants

Jose Manuel AFONSO MOREIRA
Constantinos ATHANASSOPOULOS
Hülya AYAR KAYALY
Philippe BERTRAND
Oshra BETZER
Aleksandra BONDZIC
Celine CANO
Maria Cecilia CARPINELLA
Konstantin CHEGAEV
Simon CROSS
Sabrina DALLAVALLE
Didier DESMAËLE
Vladimir DOBRICIC
Enrique DOMÍNGUEZ ÁLVAREZ
Maria Luz DURÁN-CARRIL
Thomas EFFERTH
Sündüs ERBAS CAKMAK
Nenad FILIPOVIĆGoogle Scholar
Roberta FRUTTERO
Arasu GANESAN
Alfonso GARCIA SOSA
Stefano GUGLIELMO
Attila HUNYADI
Janez ILAS
Beata KALSKA-SLOTKO
Arif KIVRAK
Giuseppe LA REGINA
Loretta LAZZARATO
Elise LEPELTIER
Oscar LOPEZ LOPEZGoogle Scholar
Miguel MACHUQUEIRO
Maria Manuel MARQUES
Florence MCCARTHY
Mattia MORI
Claudio NASTRUZZI
Sanna NIINIVEHMAS
Niamh O'BOYLE
Helena OLIVEIRA
Ryszard OSTASZEWSKI
Luigi PADUANO
Ilza PAJEVA
Catherine PASSIRANI
Olli PENTIKÄINEN
Vilma PETRIKAITE
Elena PONTIKI
Rachela POPOVTZER
Nevena PRLAINOVIC
Patrícia RIJO
Flavio RIZZOLIO
Bart ROMAN
Tamar SADAN
Maria M. M. SANTOS
Žiga SKOK
Mirjana STANIC
Kjetil TASKEN
Nanasaheb THORAT
Tihomir TOMAŠIĆ
Patrick TROUILLAS
Iztok TUREL
Maria José UMBELINO FERREIRA
Cekdar VAKIF AHMETOGLU
Andreia VALENTE
Kateřina VALENTOVÁ
Giuseppe VITIELLO
Ana VUJAČIĆ NIKEZIĆ

Anan YAGHMUR
Raivis ZALUBOVSKIS
Nace ZIDAR
Sotiris HADJIKAKOU
Christina BANTI
Camillo ROSANO
Romano SILVESTRI
Miodrag DRAGOJ
Maria Emìlia SOUSA