New diagnostic and therapeutic tools
against multidrug resistant tumours

Synthesis and nanodelivery strategies for new therapeutic tools against MDR tumours

The main objective of WG2 is to identify, via design and synthesis, new bio-active compounds that target multidrug resistance (MDR) tumours and to formulate them using nanocarriers in order to improve their solubilisation, delivery, selectivity and anticancer action using passive or active targeting, via the optimisation of pharmacokinetic properties. The identification of new substances (novel anticancer agents, natural compounds…) as modulators of MDR in tumour cells and the realisation of new pharmacological tools (nanoparticles, liposomes, self-assemblies prodrugs…) will proceed via a study of structure-activity and structure-property relationships and the clarification of MDR mechanisms. Tools and expertise will include the use of contemporary methods of synthesis and the interpretation of biological data (computational chemistry, QSAR, molecular modelling, molecular dynamics…) in order to optimise existing leads and select validated, promising and innovative pharmacological targets.

Information about WG2 meetings

WG2 Members

Total 82 participants

Aleksandra BONDZIC
Alfonso GARCIA SOSA
Ana VUJAČIĆ NIKEZIĆ
Anan YAGHMUR
Andreia PALMEIRA
Andreia VALENTE
Anne VESSIERES
Arasu GANESAN
Arif KIVRAK
Attila HUNYADI
Bart ROMAN
Beata KALSKA-SLOTKO
Camillo ROSANO
Carmen ABATE
Catherine PASSIRANI
Cekdar VAKIF AHMETOGLU
Celine CANO
Christina BANTI
Claudio NASTRUZZI
Constantinos ATHANASSOPOULOS
Didier DESMAËLE
Elena PONTIKI
Elise LEPELTIER
Enrique DOMÍNGUEZ ÁLVAREZ
Flavio RIZZOLIO
Florence MCCARTHY
Giacomo DRAGOJ
Giuseppe LA REGINA
Giuseppe VITIELLO
Helena OLIVEIRA
Hülya AYAR KAYALY
Ilza PAJEVA
Iztok TUREL
Janez ILAS
Jose Manuel AFONSO MOREIRA
Kateřina VALENTOVÁ
Kjetil TASKEN
Konstantin CHEGAEV
Loretta LAZZARATO
Luigi PADUANO
Madalena PINTO
Maria Cecilia CARPINELLA
Maria Emìlia SOUSA
Maria José UMBELINO FERREIRA
Maria Luz DURÁN-CARRIL
Maria M. M. SANTOS
Maria Manuel MARQUES
Marie MORILLIE
Mattia MORI
Miguel MACHUQUEIRO
Mirjana STANIC
Nace ZIDAR
Nanasaheb THORAT
Nenad FILIPOVIĆ
Nevena PRLAINOVIC
Niamh O'BOYLE
Nicolas CLERE
Olli PENTIKÄINEN
Oscar LOPEZ LOPEZ
Oshra BETZER
Patrícia RIJO
Patrick TROUILLAS
Philippe BERTRAND
Rachela POPOVTZER
Raivis ZALUBOVSKIS
Roberta FRUTTERO
Romano SILVESTRI
Ryszard OSTASZEWSKI
Sabrina DALLAVALLE
Sanna NIINIVEHMAS
Simon CROSS
Simona MURA
Sotiris HADJIKAKOU
Stefano GUGLIELMO
Sündüs ERBAS CAKMAK
Tamar SADAN
Thomas EFFERTH
Tihomir TOMAŠIĆ
Veronica BASTOS
Vilma PETRIKAITE
Vladimir DOBRICIC
Žiga SKOK