New diagnostic and therapeutic tools
against multidrug resistant tumours

Identification of new biomarkers and therapeutic targets for MDR tumours

The main objective of WG1 is to analyse the available data-resources on large clinical cohort of patients bearing solid tumours by bioinformatic and computational biology, to quickly integrate data of gene expression profile, proteome, RNOme/miRNOME profile in chemosensitive and isogenic MDR cancer cells, in order to identify new biomarkers predictive/diagnostic of MDR phenotype and new therapeutic targets in MDR tumours. The data will allow the identification of specific biomarkers/therapeutic targets involved in the MDR phenotype of cancer stem cells (CSCs) or in the intercellular transfer of MDR phenotype, focusing on microvesicles released by MDR tumours. By means of high-throughput pharmacogenomic and pharmacoproteomic analyses, WG1 intends to create a starting hub for WG2 to properly refine drug design/selection of natural compounds, for WG3 for the biological efficacy assay, and for WG4 to verify the safety of hitting a specific therapeutic target.

Information about WG1 meetings

WG1 Members

Total: 63 participants
Aija LINE
Aleksandra BONDZIC
Alexander TOLIOS
An WOUTERS
Ana Bela SARMENTO-RIBEIRO
Ana Cristina GONÇALVES
Ana VUJAČIĆ NIKEZIĆ
Anamaria BROZOVIC
Anan YAGHMUR
Andreas SCORILAS
Angélica FIGUEROA
Arturs ABOLS
Bilge TUNA
Camillo ROSANO
Ceyda ACILAN AYHAN
Chiara RIGANTI
Christian SPITERI
Dana JURKOVICOVA
Daria LER
Eivind HOVIG
Elena GAZZANO
Elisabeth PÉREZ-RUIZ
Evren GUNDOGDU
Gabrielle ETTENBERGER-BORNBERG
Giacomo DRAGOJ
Goran MITULOVIC
Gunhild M. MÆLANDSMO
Hugo CAIRES
Inese CAKSTINA
Ioannis P. TROUGAKOS
Irina MOREIRA
Iris Chiara SALAROGLIO
Javier DE LAS RIVAS
Jean-Pierre GILLET
Jeremy PULLICINO
Joanna KOPECKA
Jose Juan G. MARIN
Jose Manuel AFONSO MOREIRA
Lana NEZIC
Lidija TODOROVIC
M. Helena VASCONCELOS
Maria Cecilia CARPINELLA

Maria Manuel MARQUES
Marilina GARCÍA-ARANDA
Miodrag DRAGOJ
Mirza SULJAGIC
Monica Suarez KORSNES
Muriel CUENDET
Nihal KARAKAS
Nuray ERIN
Oscar BRIZ
Radka VACLAVIKOVA
Romano SILVESTRI
Ryszard OSTASZEWSKI
Soner DOGAN
Sümeyye AYDOGAN TÜRKOGLU
Tanja PANIC-JANKOVIC
Tatar GIZEM
Thomas EFFERTH
Thomas MOHR
Umut AGYÜZ
Verena PAULITSCHKE
Wolfang LINK