Training School “Targeting MDR Tumours: from natural product chemistry to nanocarrier-based formulation”
Organized by researchers of COST STRATAGEM WG2 (New therapeutic tools against MDR & Nanodelivery of the therapeutic tools) this summer school will allow to reinforce the knowledge about new bio-active compounds and drug delivery strategies to overcome therapy resistance.
The Training School will take place between 30 June and 02 July 2021 in the Department of Chemistry and Technology of Drugs, Faculty of Pharmacy and Medicine, Sapienza University.
Theoretical and practical notions on the anticancer action of NPs will allow training school participants (PhD students and Postdocs of STRATAGEM-affiliated laboratories are expected) to explore different aspects from nanoparticles (NPs) synthesis to their incorporation in nanometric carriers capable of targeting MDR tumours.
The natural products (NPs) drug discovery process will be outlined highlighting the key steps:
- hit compound identification by in silico and in vitro screening of NPs library;
- isolation and structural elucidation of NPs;
- synthesis and characterization of NPs and derivatives;
- encapsulation of the most promising NPs within nanoparticles (lipid nanocapsules and polysaccharide nanogels) to increase their bioavailability, decrease their toxicity and improve the targeting of cancer cells.
The training school will be organized around theoretical lectures on different topics (NPs chemistry, NPs library, mechanism of action of new anticancer agents, nanocarrier formulation, cancer treatments, targeting of multidrug resistant (MDR) tumours) and practical experiments (natural product chemistry, physicochemical characterisation, nanoformulation) in the laboratories of the department.
STRATAGEM members and their affiliates should contact the central email address (firstname.lastname@example.org) if they’re interested in attending.
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